Potential for imaging the high-affinity state of the 5-HT1B receptor: a comparison of three PET radioligands with differing intrinsic activity

Potential for imaging the high-affinity state of the 5-HT1B receptor: a comparison of three PET radioligands with differing intrinsic activity

Abstract Background Over the last decade, a few radioligands have been developed for PET imaging of brain 5-HT1B receptors. The 5-HT1B receptor is a G-protein-coupled receptor (GPCR) that exists in two different agonist affinity states. An agonist ligand is expected to be more sensitive towards comp...

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Bibliographic Details
Main Authors: Anton Lindberg, Ryosuke Arakawa, Tsuyoshi Nogami, Sangram Nag, Magnus Schou, Charles S. Elmore, Lars Farde, Victor W. Pike, Christer Halldin
Format: Article
Language:English
Published: SpringerOpen 2019-11-01
Series:EJNMMI Research
Subjects:
5-HT1B
PET
Radioligand
Agonist
Antagonist
Online Access:http://link.springer.com/article/10.1186/s13550-019-0570-1

Internet

http://link.springer.com/article/10.1186/s13550-019-0570-1

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