Sustained interleukin-10 delivery reduces inflammation and improves motor function after spinal cord injury

Sustained interleukin-10 delivery reduces inflammation and improves motor function after spinal cord injury

Abstract Background The anti-inflammatory cytokine interleukin-10 (IL-10) has been explored previously as a treatment method for spinal cord injury (SCI) due to its ability to attenuate pro-inflammatory cytokines and reduce apoptosis. Primary limitations when using systemic injections of IL-10 are t...

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Bibliographic Details
Main Authors: Daniel J. Hellenbrand, Kaitlyn A. Reichl, Benjamin J. Travis, Mallory E. Filipp, Andrew S. Khalil, Domenic J. Pulito, Ashley V. Gavigan, Elizabeth R. Maginot, Mitchell T. Arnold, Alexander G. Adler, William L. Murphy, Amgad S. Hanna
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Journal of Neuroinflammation
Subjects:
Interleukin-10
Macrophages
Microglia
Spinal cord injury
Inflammation
Online Access:http://link.springer.com/article/10.1186/s12974-019-1479-3

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http://link.springer.com/article/10.1186/s12974-019-1479-3

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