Expanded ataxin-7 cause toxicity by inducing ROS production from NADPH oxidase complexes in a stable inducible Spinocerebellar ataxia type 7 (SCA7) model

Expanded ataxin-7 cause toxicity by inducing ROS production from NADPH oxidase complexes in a stable inducible Spinocerebellar ataxia type 7 (SCA7) model

<p>Abstract</p> <p>Background</p> <p>Spinocerebellar ataxia type 7 (SCA7) is one of nine inherited neurodegenerative disorders caused by polyglutamine (polyQ) expansions. Common mechanisms of disease pathogenesis suggested for polyQ disorders include aggregation of the...

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Bibliographic Details
Main Authors: Ajayi Abiodun, Yu Xin, Lindberg Staffan, Langel Ülo, Ström Anna-Lena
Format: Article
Language:English
Published: BMC 2012-07-01
Series:BMC Neuroscience
Subjects:
Ataxin-7
NADPH oxidase complex
Neurodegeneration
Oxidative stress
Polyglutamine
SCA7
Online Access:http://www.biomedcentral.com/1471-2202/13/86

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http://www.biomedcentral.com/1471-2202/13/86

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