GenToS: Use of Orthologous Gene Information to Prioritize Signals from Human GWAS.

Genome-wide association studies (GWAS) evaluate associations between genetic variants and a trait or disease of interest free of prior biological hypotheses. GWAS require stringent correction for multiple testing, with genome-wide significance typically defined as association p-value <5*10-8. Thi...

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Bibliographic Details
Main Authors: Anselm S Hoppmann, Pascal Schlosser, Rolf Backofen, Ekkehart Lausch, Anna Köttgen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5017755?pdf=render