Anti-Proliferation and Anti-Invasion Effects of Diosgenin on Gastric Cancer BGC-823 Cells with HIF-1α shRNAs

Anti-Proliferation and Anti-Invasion Effects of Diosgenin on Gastric Cancer BGC-823 Cells with HIF-1α shRNAs

Drug resistance is a major factor for the limited efficacy of chemotherapy in gastric cancer treatment. Hypoxia-inducible factor-1α (HIF-1α), a central transcriptional factor in hypoxia, is suggested to participate in the resistance. Here, we identified a hypoxia-mimic (cobalt chloride) sensitive ga...

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Bibliographic Details
Main Authors: Yuan-Neng Chou, Bin Pang, Pin-kang Wei, Ci-An Zhang, Bo Liu, Zhi-Feng Qin, Qian-Jue Tang, Zhu-Jun Mao
Format: Article
Language:English
Published: MDPI AG 2012-05-01
Series:International Journal of Molecular Sciences
Subjects:
gastric cancer
HIF-1α
hypoxia
shRNA
diosgenin
Online Access:http://www.mdpi.com/1422-0067/13/5/6521

Internet

http://www.mdpi.com/1422-0067/13/5/6521

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