Glibenclamide for the Treatment of Ischemic and Hemorrhagic Stroke

Glibenclamide for the Treatment of Ischemic and Hemorrhagic Stroke

Ischemic and hemorrhagic strokes are associated with severe functional disability and high mortality. Except for recombinant tissue plasminogen activator, therapies targeting the underlying pathophysiology of central nervous system (CNS) ischemia and hemorrhage are strikingly lacking. Sur1-regulated...

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Bibliographic Details
Main Authors: Nicholas Caffes, David B. Kurland, Volodymyr Gerzanich, J. Marc Simard
Format: Article
Language:English
Published: MDPI AG 2015-03-01
Series:International Journal of Molecular Sciences
Subjects:
ischemic stroke
subarachnoid hemorrhage
Sur1-Trpm4 channels
KATP channels
glibenclamide
cerebral edema
necrotic cell death
Online Access:http://www.mdpi.com/1422-0067/16/3/4973

Internet

http://www.mdpi.com/1422-0067/16/3/4973

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