A downstream CpG island controls transcript initiation and elongation and the methylation state of the imprinted Airn macro ncRNA promoter.

A downstream CpG island controls transcript initiation and elongation and the methylation state of the imprinted Airn macro ncRNA promoter.

A CpG island (CGI) lies at the 5' end of the Airn macro non-protein-coding (nc) RNA that represses the flanking Igf2r promoter in cis on paternally inherited chromosomes. In addition to being modified on maternally inherited chromosomes by a DNA methylation imprint, the Airn CGI shows two unusu...

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Bibliographic Details
Main Authors: Martha V Koerner, Florian M Pauler, Quanah J Hudson, Federica Santoro, Anna Sawicka, Philipp M Guenzl, Stefan H Stricker, Yvonne M Schichl, Paulina A Latos, Ruth M Klement, Katarzyna E Warczok, Jacek Wojciechowski, Christian Seiser, Robert Kralovics, Denise P Barlow
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3291542?pdf=render

Internet

http://europepmc.org/articles/PMC3291542?pdf=render

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