Transport Deficiency Is the Molecular Basis of Candida albicans Resistance to Antifungal Oligopeptides

Transport Deficiency Is the Molecular Basis of Candida albicans Resistance to Antifungal Oligopeptides

Oligopeptides incorporating N3-(4-methoxyfumaroyl)-L-2,3-diaminopropanoic acid (FMDP), an inhibitor of glucosamine-6-phosphate synthase, exhibited growth inhibitory activity against Candida albicans, with minimal inhibitory concentration values in the 0.05–50 μg mL-1 range. Uptake by the peptide per...

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Bibliographic Details
Main Authors: Marta Schielmann, Piotr Szweda, Katarzyna Gucwa, Marcin Kawczyński, Maria J. Milewska, Dorota Martynow, Joachim Morschhäuser, Sławomir Milewski
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Microbiology
Subjects:
Candida albicans
oligopeptides
resistance mechanism
permease
antifungals
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2017.02154/full

Internet

http://journal.frontiersin.org/article/10.3389/fmicb.2017.02154/full

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