Mechanisms of increased risk of tumorigenesis in <it>Atm </it>and <it>Brca1 </it>double heterozygosity

Mechanisms of increased risk of tumorigenesis in <it>Atm </it>and <it>Brca1 </it>double heterozygosity

<p>Abstract</p> <p>Background</p> <p>Both epidemiological and experimental studies suggest that heterozygosity for a single gene is linked with tumorigenesis and heterozygosity for two genes increases the risk of tumor incidence. Our previous work has demonstrated that...

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Bibliographic Details
Main Authors: Wang Jufang, Su Fengtao, Smilenov Lubomir B, Zhou Libin, Hu Wentao, Ding Nan, Zhou Guangming
Format: Article
Language:English
Published: BMC 2011-08-01
Series:Radiation Oncology
Subjects:
heterozygosity
haploinsufficiency
tumorigenesis
DNA damage
cell cycle checkpoint
genomic instability
Online Access:http://www.ro-journal.com/content/6/1/96

Internet

http://www.ro-journal.com/content/6/1/96

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