Early pulmonary response is critical for extra-pulmonary carbon nanoparticle mediated effects: comparison of inhalation versus intra-arterial infusion exposures in mice

Early pulmonary response is critical for extra-pulmonary carbon nanoparticle mediated effects: comparison of inhalation versus intra-arterial infusion exposures in mice

Abstract Background The death toll associated with inhaled ambient particulate matter (PM) is attributed mainly to cardio-vascular rather than pulmonary effects. However, it is unclear whether the key event for cardiovascular impairment is particle translocation from lung to circulation (direct effe...

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Bibliographic Details
Main Authors: Koustav Ganguly, Dariusch Ettehadieh, Swapna Upadhyay, Shinji Takenaka, Thure Adler, Erwin Karg, Fritz Krombach, Wolfgang G. Kreyling, Holger Schulz, Otmar Schmid, Tobias Stoeger
Format: Article
Language:English
Published: BMC 2017-06-01
Series:Particle and Fibre Toxicology
Subjects:
Inhaled soot
Ultrafine particulate matter
Inflammation
Lung
Heart
Aorta
Online Access:http://link.springer.com/article/10.1186/s12989-017-0200-x

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http://link.springer.com/article/10.1186/s12989-017-0200-x

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