Carbonic Anhydrase 12 Protects Endplate Cartilage From Degeneration Regulated by IGF-1/PI3K/CREB Signaling Pathway

Carbonic Anhydrase 12 Protects Endplate Cartilage From Degeneration Regulated by IGF-1/PI3K/CREB Signaling Pathway

Lumbar intervertebral disc degeneration (IVDD) is the most common cause of low back pain (LBP). Among all the factors leading to IVDD, lumbar cartilage endplate (LCE) degeneration is considered a key factor. In the present study, we investigate the effect and regulation of carbonic anhydrase 12 (CA1...

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Bibliographic Details
Main Authors: Xing Zhao, Panyang Shen, Haidong Li, Yute Yang, Jiandong Guo, Shuai Chen, Yan Ma, Jiamin Sheng, Shuying Shen, Gang Liu, Xiangqian Fang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
endplate cartilage
carbonic anhydrase 12
IGF-1
low back pain
degeneration
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.595969/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.595969/full

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