Rational Targeting of Cdc42 Overcomes Drug Resistance of Multiple Myeloma

Rational Targeting of Cdc42 Overcomes Drug Resistance of Multiple Myeloma

Multiple myeloma (MM) drug resistance highlights a need for alternative therapeutic strategies. In this study, we show that CASIN, a selective inhibitor of cell division cycle 42 (Cdc42) GTPase, inhibited proliferation and survival of melphalan/bortezomib-resistant MM cells more profoundly than that...

Full description

Bibliographic Details
Main Authors: Phuong Nguyen, Jayati Chakrabarti, Yuan Li, Khalid W. Kalim, Mengnan Zhang, Lin Zhang, Yi Zheng, Fukun Guo
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Oncology
Subjects:
multiple myeloma
Cdc42
CASIN
drug resistance
p-ERK
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00958/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2019.00958/full

Similar Items