Characterization of temperature-sensitive leak K+ currents and expression of TRAAK, TREK-1, and TREK2 channels in dorsal root ganglion neurons of rats

Characterization of temperature-sensitive leak K+ currents and expression of TRAAK, TREK-1, and TREK2 channels in dorsal root ganglion neurons of rats

Abstract Leak K+ currents are mediated by two-pore domain K+ (K2P) channels and are involved in controlling neuronal excitability. Of 15 members of K2P channels cloned so far, TRAAK, TREK-1, and TREK-2 are temperature sensitive. In the present study, we show that strong immunoreactivity of TRAAK, TR...

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Bibliographic Details
Main Authors: Viacheslav Viatchenko-Karpinski, Jennifer Ling, Jianguo G. Gu
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Molecular Brain
Subjects:
Dorsal root ganglion neurons
Leak K+ currents
Two-pore domain K+ channels
Temperature sensitivity
Pain
Cold allodynia
Online Access:http://link.springer.com/article/10.1186/s13041-018-0384-5

Internet

http://link.springer.com/article/10.1186/s13041-018-0384-5

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