Dimethyl fumarate reduces hepatocyte senescence following paracetamol exposure

Dimethyl fumarate reduces hepatocyte senescence following paracetamol exposure

Summary: Liver disease is a major cause of premature death. Oxidative stress in the liver represents a key disease driver. Compounds, such as dimethyl fumarate (DMF), can activate the antioxidant response and are used clinically to treat disease. In this study, we tested the protective properties of...

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Bibliographic Details
Main Authors: Jose Meseguer-Ripolles, Baltasar Lucendo-Villarin, Carl Tucker, Sofia Ferreira-Gonzalez, Natalie Homer, Yu Wang, Philip J. Starkey Lewis, Enrique M Toledo, Esther Mellado-Gomez, Joanna Simpson, Oliver Flint, Himjyot Jaiswal, Nicola L. Beer, Allan E. Karlsen, Stuart J. Forbes, James W. Dear, Jeremy Hughes, David C. Hay
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:iScience
Subjects:
Molecular biology
Toxicology
Cell biology
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221005204

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http://www.sciencedirect.com/science/article/pii/S2589004221005204

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