Pretargeting of internalizing trastuzumab and cetuximab with a 18F-tetrazine tracer in xenograft models

Pretargeting of internalizing trastuzumab and cetuximab with a 18F-tetrazine tracer in xenograft models

Abstract Background Pretargeting-based approaches are being investigated for radioimmunoimaging and therapy applications to reduce the effective radiation burden to the patient. To date, only a few studies have used short-lived radioisotopes for pretargeting of antibodies, and such examples with int...

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Bibliographic Details
Main Authors: Outi Keinänen, Kimberly Fung, Jacob Pourat, Vilma Jallinoja, Delphine Vivier, NagaVara Kishore Pillarsetty, Anu J. Airaksinen, Jason S. Lewis, Brian M. Zeglis, Mirkka Sarparanta
Format: Article
Language:English
Published: SpringerOpen 2017-12-01
Series:EJNMMI Research
Subjects:
Fluorine-18
Inverse electron-demand Diels-Alder (IEDDA) reaction
Pretargeting
Tetrazine
Trans-cyclooctene
Online Access:http://link.springer.com/article/10.1186/s13550-017-0344-6

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http://link.springer.com/article/10.1186/s13550-017-0344-6

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