2-Phenyl-tetrahydropyrimidine-4(1H)-ones – cyclic benzaldehyde aminals as precursors for functionalised β2-amino acids

2-Phenyl-tetrahydropyrimidine-4(1H)-ones – cyclic benzaldehyde aminals as precursors for functionalised β2-amino acids

Novel procedures have been developed to condense benzaldehyde effectively with β-amino acid amides to cyclic benzyl aminals. Double carbamate protection of the heterocycle resulted in fully protected chiral β-alanine derivatives. These serve as universal precursors for the asymmetric synthesis of fu...

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Bibliographic Details
Main Authors: Markus Nahrwold, Arvydas Stončius, Anna Penner, Beate Neumann, Hans-Georg Stammler, Norbert Sewald
Format: Article
Language:English
Published: Beilstein-Institut 2009-09-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
β2-amino acids
cyclocondensation
diastereoselective alkylation
N,N-acetals
peptidomimetics
ring opening
self-regeneration of stereocentres (SRS)
Online Access:https://doi.org/10.3762/bjoc.5.43

Internet

https://doi.org/10.3762/bjoc.5.43

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