Aggregation is a Context-Dependent Constraint on Protein Evolution

Aggregation is a Context-Dependent Constraint on Protein Evolution

Solubility is a requirement for many cellular processes. Loss of solubility and aggregation can lead to the partial or complete abrogation of protein function. Thus, understanding the relationship between protein evolution and aggregation is an important goal. Here, we analysed two deep mutational s...

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Bibliographic Details
Main Authors: Michele Monti, Alexandros Armaos, Marco Fantini, Annalisa Pastore, Gian Gaetano Tartaglia
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Molecular Biosciences
Subjects:
protein aggregation
computational model
deep scanning
cellular fitness
evolution
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.678115/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2021.678115/full

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