A pathogen-derived effector modulates host glucose metabolism by arginine GlcNAcylation of HIF-1α protein.
The essential role of pathogens in host metabolism is widely recognized, yet the mechanisms by which they affect host physiology remain to be fully defined. Here, we found that NleB, an enteropathogenic Escherichia coli (EPEC) type III secretion system effector known to possess N-acetylglucosamine (...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2018-08-01
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| Series: | PLoS Pathogens |
| Online Access: | http://europepmc.org/articles/PMC6117090?pdf=render |