Risperidone-induced weight gain is mediated through shifts in the gut microbiome and suppression of energy expenditure

Risperidone-induced weight gain is mediated through shifts in the gut microbiome and suppression of energy expenditure

Risperidone is a second-generation antipsychotic that causes weight gain. We hypothesized that risperidone-induced shifts in the gut microbiome are mechanistically involved in its metabolic consequences. Wild-type female C57BL/6J mice treated with risperidone (80 μg/day) exhibited significant excess...

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Bibliographic Details
Main Authors: Sarah M. Bahr, Benjamin J. Weidemann, Ana N. Castro, John W. Walsh, Orlando deLeon, Colin M.L. Burnett, Nicole A. Pearson, Daryl J. Murry, Justin L. Grobe, John R. Kirby
Format: Article
Language:English
Published: Elsevier 2015-11-01
Series:EBioMedicine
Subjects:
Risperidone induced weight gain
Gut microbiome
Suppression of energy expenditure
Fecal transfer
Phage transfer
Non-aerobic resting metabolic rate
Online Access:http://www.sciencedirect.com/science/article/pii/S235239641530181X

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http://www.sciencedirect.com/science/article/pii/S235239641530181X

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