The chemical chaperone 4-phenylbutyrate inhibits adipogenesis by modulating the unfolded protein response[S]

The chemical chaperone 4-phenylbutyrate inhibits adipogenesis by modulating the unfolded protein response[S]

Recent studies have shown a link between obesity and endoplasmic reticulum (ER) stress. Perturbations in ER homeostasis cause ER stress and activation of the unfolded protein response (UPR). Adipocyte differentiation contributes to weight gain, and we have shown that markers of ER stress/UPR activat...

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Bibliographic Details
Main Authors: Sana Basseri, Šárka Lhoták, Arya M. Sharma, Richard C. Austin
Format: Article
Language:English
Published: Elsevier 2009-12-01
Series:Journal of Lipid Research
Subjects:
ER stress
obesity
adipocyte differentiation
3T3-L1
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520306714

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http://www.sciencedirect.com/science/article/pii/S0022227520306714

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