The Opening of ATP-Sensitive K+ Channels Protects H9c2 Cardiac Cells Against the High Glucose-Induced Injury and Inflammation by Inhibiting the ROS-TLR4-Necroptosis Pathway

The Opening of ATP-Sensitive K+ Channels Protects H9c2 Cardiac Cells Against the High Glucose-Induced Injury and Inflammation by Inhibiting the ROS-TLR4-Necroptosis Pathway

Background/Aims: Hyperglycemia activates multiple signaling molecules, including reactive oxygen species (ROS), toll-like receptor 4 (TLR4), receptor-interacting protein 3 (RIP3, a kinase promoting necroptosis), which mediate hyperglycemia-induced cardiac injury. This study explored whether inhibiti...

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Bibliographic Details
Main Authors: Weijie Liang, Meiji Chen, Dongdan Zheng, Jianhao Li, Mingcai Song, Wenzhu Zhang, Jianqiang Feng, Jun Lan
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-02-01
Series:Cellular Physiology and Biochemistry
Subjects:
Reactive oxygen species
Toll-like receptor 4
Necroptosis
High glucose
H9c2 cardiac cells
ATP-sensitive K+ channel
Online Access:http://www.karger.com/Article/FullText/461391

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http://www.karger.com/Article/FullText/461391

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