Changes in the cellular microRNA profile by the intracellular expression of HIV-1 Tat regulator: A potential mechanism for resistance to apoptosis and impaired proliferation in HIV-1 infected CD4+ T cells.

Changes in the cellular microRNA profile by the intracellular expression of HIV-1 Tat regulator: A potential mechanism for resistance to apoptosis and impaired proliferation in HIV-1 infected CD4+ T cells.

HIV-1 induces changes in the miRNA expression profile of infected CD4+ T cells that could improve viral replication. HIV-1 regulator Tat modifies the cellular gene expression and has been appointed as an RNA silencing suppressor. Tat is a 101-residue protein codified by two exons that regulates the...

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Bibliographic Details
Main Authors: María Sánchez-Del Cojo, María Rosa López-Huertas, Francisco Díez-Fuertes, Sara Rodríguez-Mora, Mercedes Bermejo, Guillermo López-Campos, Elena Mateos, Laura Jiménez-Tormo, Francisco Gómez-Esquer, Gema Díaz-Gil, José Alcamí, Mayte Coiras
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5624617?pdf=render

Internet

http://europepmc.org/articles/PMC5624617?pdf=render

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