Recognition of Multiple Hybrid Insulin Peptides by a Single Highly Diabetogenic T-Cell Receptor

Recognition of Multiple Hybrid Insulin Peptides by a Single Highly Diabetogenic T-Cell Receptor

The mechanisms underlying the major histocompatibility complex class II (MHCII) type 1 diabetes (T1D) association remain incompletely understood. We have previously shown that thymocytes expressing the highly diabetogenic, I-Ag7-restricted 4.1-T-cell receptor (TCR) are MHCII-promiscuous, and that, i...

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Bibliographic Details
Main Authors: Daniel Parras, Patricia Solé, Thomas Delong, Pere Santamaría, Pau Serra
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Immunology
Subjects:
autoimmunity
type 1 diabetes
epitope discovery
TCR-transgenic NOD mice
hybrid insulin peptides
antigenic promiscuity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.737428/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.737428/full

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