Transient redirection of T cells for adoptive cell therapy with telomerase-specific T helper cell receptors isolated from long term survivors after cancer vaccination

Transient redirection of T cells for adoptive cell therapy with telomerase-specific T helper cell receptors isolated from long term survivors after cancer vaccination

Adoptive cell therapy (ACT) with retargeted T cells has produced remarkable clinical responses against cancer, but also serious toxicity. Telomerase is overexpressed in most cancers, but also expressed in some normal cells, raising safety concerns. We hypothesize that ACT with T-helper cell receptor...

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Bibliographic Details
Main Authors: Jon Amund Kyte, Anne Fåne, Martin Pule, Gustav Gaudernack
Format: Article
Language:English
Published: Taylor & Francis Group 2019-04-01
Series:OncoImmunology
Subjects:
t-helper cell
mrna
telomerase
adoptive cell therapy
t cell receptor
dp4
cancer
immunotherapy
long-term survivor
retargeted t cell
Online Access:http://dx.doi.org/10.1080/2162402X.2019.1565236

Internet

http://dx.doi.org/10.1080/2162402X.2019.1565236

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