Global Distribution of Human Protoparvoviruses

• Main Authors: Elina Väisänen, Ushanandini Mohanraj, Paula M. Kinnunen, Pikka Jokelainen, Haider Al-Hello, Ali M. Barakat, Mohammadreza Sadeghi, Farid A. Jalilian, Amir Majlesi, Moses Masika, Dufton Mwaengo, Omu Anzala, Eric Delwart, Olli Vapalahti, Klaus Hedman, Maria Söderlund-Venermo
• Format: Article
• Language: English
• Published: Centers for Disease Control and Prevention 2018-07-01
• Series: Emerging Infectious Diseases
• Subjects: human protoparvovirus; viruses; parvovirus; parvoviridae; bufavirus; tusavirus
• Online Access: https://wwwnc.cdc.gov/eid/article/24/7/17-2128_article

Development of next-generation sequencing and metagenomics has revolutionized detection of novel viruses. Among these viruses are 3 human protoparvoviruses: bufavirus, tusavirus, and cutavirus. These viruses have been detected in feces of children with diarrhea. In addition, cutavirus has been detected in skin biopsy specimens of cutaneous T-cell lymphoma patients in France and in 1 melanoma patient in Denmark. We studied seroprevalences of IgG against bufavirus, tusavirus, and cutavirus in various populations (n = 840), and found a striking geographic difference in prevalence of bufavirus IgG. Although prevalence was low in adult populations in Finland (1.9%) and the United States (3.6%), bufavirus IgG was highly prevalent in populations in Iraq (84.8%), Iran (56.1%), and Kenya (72.3%). Conversely, cutavirus IgG showed evenly low prevalences (0%–5.6%) in all cohorts, and tusavirus IgG was not detected. These results provide new insights on the global distribution and endemic areas of protoparvoviruses.