TRIB2 modulates proteasome function to reduce ubiquitin stability and protect liver cancer cells against oxidative stress

TRIB2 modulates proteasome function to reduce ubiquitin stability and protect liver cancer cells against oxidative stress

Abstract The regulation of homeostasis in the Ubiquitin (Ub) proteasome system (UPS) is likely to be important for the development of liver cancer. Tribbles homolog 2 (TRIB2) is known to affect Ub E3 ligases (E3s) in liver cancer. However, whether TRIB2 regulates the UPS in other ways and the releva...

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Bibliographic Details
Main Authors: Susu Guo, Yuxin Chen, Yueyue Yang, Xiao Zhang, Lifang Ma, Xiangfei Xue, Yongxia Qiao, Jiayi Wang
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-020-03299-8

Internet

https://doi.org/10.1038/s41419-020-03299-8

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