IRAK-M regulates chromatin remodeling in lung macrophages during experimental sepsis.

Sepsis results in a profound state of immunosuppression, which is temporally associated with impaired leukocyte function. The mechanism of leukocyte reprogramming in sepsis is incompletely understood. In this study, we explored mechanisms contributing to dysregulated inflammatory cytokine expression...

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Bibliographic Details
Main Authors: Kenneth Lyn-Kew, Eric Rich, Xianying Zeng, Haitao Wen, Steven L Kunkel, Michael W Newstead, Urvashi Bhan, Theodore J Standiford
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-06-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2886833?pdf=render