Modeling Bainbridge-Ropers Syndrome in Xenopus laevis Embryos

Modeling Bainbridge-Ropers Syndrome in Xenopus laevis Embryos

The Additional sex combs-like (ASXL1-3) genes are linked to human neurodevelopmental disorders. The de novo truncating variants in ASXL1-3 proteins serve as the genetic basis for severe neurodevelopmental diseases such as Bohring-Opitz, Shashi-Pena, and Bainbridge-Ropers syndromes, respectively. The...

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Bibliographic Details
Main Authors: Hava Lichtig, Artyom Artamonov, Hanna Polevoy, Christine D. Reid, Stephanie L. Bielas, Dale Frank
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Physiology
Subjects:
Bainbridge-Ropers syndrome
ASXL3 protein
Xenopus laevis embryos
neurodevelopmental disease model
neural crest
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00075/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2020.00075/full

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