Inhibition of mitochondrial function induces an integrated stress response in oligodendroglia

Inhibition of mitochondrial function induces an integrated stress response in oligodendroglia

Maternal inheritance of a pathogenic point mutation within complex I of the mitochondrial genome causes Leber's hereditary optic neuropathy (LHON), resulting in the neurodegeneration and demyelination of the optic nerve. The integrated stress response (ISR), a signaling pathway that responds to...

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Bibliographic Details
Main Authors: Jillian M. Silva, Alice Wong, Valerio Carelli, Gino A. Cortopassi
Format: Article
Language:English
Published: Elsevier 2009-05-01
Series:Neurobiology of Disease
Subjects:
Integrated stress response
Mitochondria
Complex I
LHON
Retrograde signaling
Oligodendroglia
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996109000333

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http://www.sciencedirect.com/science/article/pii/S0969996109000333

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