MicroRNA delivery mediated by PEGylated polyethylenimine for prostate cancer therapy

MicroRNA delivery mediated by PEGylated polyethylenimine for prostate cancer therapy

A microRNA (miRNA) nanomedicine PEG-PEI/miR-221/222 was synthesized based on PEGylated polyethylenimine PEG-PEI and used to transfect prostate cancer cells (PC-3) in vitro. Gel retardation assay confirmed the formation of nanomedicine, of which the zeta potential and particle size were determined by...

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Bibliographic Details
Main Authors: CY Chen, GY Li, L Zhang, XH Huang, D Cheng, SC Wu, CZ Xu, JH Zhou, L Xun
Format: Article
Language:English
Published: De Gruyter 2018-12-01
Series:Open Chemistry
Subjects:
non-viral vector
prostate cancer
microrna delivery
nanomedicine
sirt1 gene
Online Access:https://doi.org/10.1515/chem-2018-0138

Internet

https://doi.org/10.1515/chem-2018-0138

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