Lychee seed polyphenol protects blood–retinal barrier by increasing tight joint proteins and inhibiting the activation of TLR4/MYD88/NF-κB-mediated NLRP3 inflammasome

Lychee seed polyphenol protects blood–retinal barrier by increasing tight joint proteins and inhibiting the activation of TLR4/MYD88/NF-κB-mediated NLRP3 inflammasome

Emerging evidence indicates that blood–retinal barrier (BRB) damage is the main cause of diabetic retinopathy (DR), and the downregulation of tight proteins (TJs) located between endothelial cells and the activation of NLRP3 inflammasome-mediated inflammation in Müller cells result in BRB injury. In...

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Bibliographic Details
Main Authors: Jing Wei, Xiao-Hong Xiang, Yong Tang, Da-Lian Qin, Jian-Ming Wu, Chong-Lin Yu, Wen-Qiao Qiu, An-Guo Wu, Hong-Bin Lv
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Food and Agricultural Immunology
Subjects:
lychee seed polyphenol
blood–retinal barrier
tight proteins
nlrp3 inflammasome
tlr4/myd88/nf-κb
Online Access:http://dx.doi.org/10.1080/09540105.2021.1968352

Internet

http://dx.doi.org/10.1080/09540105.2021.1968352

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