Plag1 and Plagl2 have overlapping and distinct functions in telencephalic development

Plag1 and Plagl2 have overlapping and distinct functions in telencephalic development

The Plag gene family has three members; Plagl1/Zac1, which is a tumor suppressor gene, and Plag1 and Plagl2, which are proto-oncogenes. All three genes are known to be expressed in embryonic neural progenitors, and Zac1 regulates proliferation, neuronal differentiation and migration in the developin...

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Bibliographic Details
Main Authors: Lata Adnani, Rajiv Dixit, Xingyu Chen, Anjali Balakrishnan, Harshil Modi, Yacine Touahri, Cairine Logan, Carol Schuurmans
Format: Article
Language:English
Published: The Company of Biologists 2018-11-01
Series:Biology Open
Subjects:
Plag gene family
Zinc finger transcription factors
Neocortical development
Neural progenitor proliferation
Neurogenesis
Telencephalic patterning
Online Access:http://bio.biologists.org/content/7/11/bio038661

Internet

http://bio.biologists.org/content/7/11/bio038661

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