A chemical screen probing the relationship between mitochondrial content and cell size.

The cellular content of mitochondria changes dynamically during development and in response to external stimuli, but the underlying mechanisms remain obscure. To systematically identify molecular probes and pathways that control mitochondrial abundance, we developed a high-throughput imaging assay t...

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Bibliographic Details
Main Authors: Toshimori Kitami, David J Logan, Joseph Negri, Thomas Hasaka, Nicola J Tolliday, Anne E Carpenter, Bruce M Spiegelman, Vamsi K Mootha
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3315575?pdf=render