NFIL3 Facilitates Neutrophil Autophagy, Neutrophil Extracellular Trap Formation and Inflammation During Gout via REDD1-Dependent mTOR Inactivation

NFIL3 Facilitates Neutrophil Autophagy, Neutrophil Extracellular Trap Formation and Inflammation During Gout via REDD1-Dependent mTOR Inactivation

Autophagy pathways play an important role in immunity and inflammation via pathogen clearance mechanisms mediated by immune cells, such as macrophages and neutrophils. In particular, autophagic activity is essential for the release of neutrophil extracellular traps (NETs), a distinct form of active...

Full description

Bibliographic Details
Main Authors: Honghu Tang, Chunyu Tan, Xue Cao, Yi Liu, Hua Zhao, Yi Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Medicine
Subjects:
gout
NFIL3
REDD1
mTOR pathway
autophagy
extracellular neutrophil traps
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2021.692781/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2021.692781/full

Similar Items