Distinct sites on ABCA1 control distinct steps required for cellular release of phospholipids1s□

Distinct sites on ABCA1 control distinct steps required for cellular release of phospholipids1s□

The loss of ABCA1 function leads to Tangier dyslipidemia in humans and to a Tangier-like phenotype in mice, by impairing the transformation of nascent apolipoproteins into mature HDL particles. Mechanistically this ensues from the inability of cells to release membrane lipids and cholesterol. Wherea...

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Bibliographic Details
Main Authors: Véronique Rigot, Yannick Hamon, Olivier Chambenoit, Mélanie Alibert, Nicolas Duverger, Giovanna Chimini
Format: Article
Language:English
Published: Elsevier 2002-12-01
Series:Journal of Lipid Research
Subjects:
ABC transporter
lipid flipping
structure/function map
membrane topology
Tangier disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520327358

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http://www.sciencedirect.com/science/article/pii/S0022227520327358

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