Heterologous Cytomegalovirus and Allo-Reactivity by Shared T Cell Receptor Repertoire in Kidney Transplantation

Heterologous Cytomegalovirus and Allo-Reactivity by Shared T Cell Receptor Repertoire in Kidney Transplantation

Cytomegalovirus (CMV) infection is associated with allograft rejection but the mechanisms behind are poorly defined yet. Although cross-reactivity of T cells to alloantigen and CMV has been hypothesized, direct evidence in patients is lacking. In this observational cohort study, we tested the pre-tr...

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Bibliographic Details
Main Authors: Lucia Stranavova, Ondrej Pelak, Michael Svaton, Petra Hruba, Eva Fronkova, Antonij Slavcev, Klara Osickova, Jana Maluskova, Petr Hubacek, Jiri Fronek, Petra Reinke, Hans-Dieter Volk, Tomas Kalina, Ondrej Viklicky
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Immunology
Subjects:
kidney transplantation
cytomegalovirus
ELISPOT
cross-reactivity
rejection
heterologous immunity
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02549/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02549/full

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