Genetic perturbation of IFN-α transcriptional modulators in human endothelial cells uncovers pivotal regulators of angiogenesis

Genetic perturbation of IFN-α transcriptional modulators in human endothelial cells uncovers pivotal regulators of angiogenesis

Interferon-α (IFN-α) comprises a family of 13 cytokines involved in the modulation of antiviral, immune, and anticancer responses by orchestrating a complex transcriptional network. The activation of IFN-α signaling pathway in endothelial cells results in decreased proliferation and migration, ultim...

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Bibliographic Details
Main Authors: Francesco Ciccarese, Angela Grassi, Lorenza Pasqualini, Stefania Rosano, Alessio Noghero, Francesca Montenegro, Federico Bussolino, Barbara Di Camillo, Lorenzo Finesso, Gianna Maria Toffolo, Stefania Mitola, Stefano Indraccolo
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
IFN-α
Transcriptional modulators
Regulatory network
CXCL10
Angiogenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037020305158

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http://www.sciencedirect.com/science/article/pii/S2001037020305158

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