Pretreatment of cardiac progenitor cells with bradykinin attenuates H2O2-induced cell apoptosis and improves cardiac function in rats by regulating autophagy

Pretreatment of cardiac progenitor cells with bradykinin attenuates H2O2-induced cell apoptosis and improves cardiac function in rats by regulating autophagy

Abstract Background Previous studies have demonstrated that human cardiac c-Kit+ progenitor cells (hCPCs) can effectively improve ischemic heart disease. However, the major challenge in applying hCPCs to clinical therapy is the low survival rate of graft hCPCs in the host heart, which limited the be...

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Bibliographic Details
Main Authors: Chan Wu, Xiao-Xia Zhou, Jing-Zhou Li, Hai-Feng Qiang, Yan Wang, Gang Li
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Stem Cell Research & Therapy
Subjects:
Bradykinin
Cardiac c-kit+ progenitor cells
Myocardial infarction
Autophagy
Apoptosis
Online Access:https://doi.org/10.1186/s13287-021-02503-6

Internet

https://doi.org/10.1186/s13287-021-02503-6

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