A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis

A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis

RAD18 is an important protein in trans-lesion synthesis, an error-prone damage-tolerant mode of DNA replication. Here the authors show that MAGE-A4 stabilizes RAD18 and allows cancer cells to maintain on-going DNA synthesis in the face of genotoxic injury.

Bibliographic Details
Main Authors: Yanzhe Gao, Elizabeth Mutter-Rottmayer, Alicia M. Greenwalt, Dennis Goldfarb, Feng Yan, Yang Yang, Raquel C. Martinez-Chacin, Kenneth H. Pearce, Satoshi Tateishi, Michael B. Major, Cyrus Vaziri
Format: Article
Language:English
Published: Nature Publishing Group 2016-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms12105

Internet

https://doi.org/10.1038/ncomms12105

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