CDK2 and PKA mediated-sequential phosphorylation is critical for p19INK4d function in the DNA damage response.

CDK2 and PKA mediated-sequential phosphorylation is critical for p19INK4d function in the DNA damage response.

DNA damage triggers a phosphorylation-based signaling cascade known as the DNA damage response. p19INK4d, a member of the INK4 family of CDK4/6 inhibitors, has been reported to participate in the DNA damage response promoting DNA repair and cell survival. Here, we provide mechanistic insight into th...

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Bibliographic Details
Main Authors: Mariela C Marazita, M Florencia Ogara, Silvina V Sonzogni, Marcelo Martí, Nelson J Dusetti, Omar P Pignataro, Eduardo T Cánepa
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22558186/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22558186/?tool=EBI

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