Comparative analysis of homologous aminopeptidase PepN from pathogenic and non-pathogenic mycobacteria reveals divergent traits.

Comparative analysis of homologous aminopeptidase PepN from pathogenic and non-pathogenic mycobacteria reveals divergent traits.

Mycobacterium tuberculosis (Mtb) secretes proteases and peptidases to subjugate its host. Out of its sixty plus proteases, atleast three are reported to reach host macrophages. In this study, we show that Mtb also delivers a lysyl alanine aminopeptidase, PepN (Rv2467) into host macrophage cytosol. O...

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Bibliographic Details
Main Authors: Nishant Sharma, Suruchi Aggarwal, Saravanan Kumar, Rahul Sharma, Konika Choudhury, Niti Singh, Praapti Jayaswal, Renu Goel, Saima Wajid, Amit Kumar Yadav, Krishnamohan Atmakuri
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0215123

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https://doi.org/10.1371/journal.pone.0215123

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