IFITM Proteins Restrict HIV-1 Infection by Antagonizing the Envelope Glycoprotein

IFITM Proteins Restrict HIV-1 Infection by Antagonizing the Envelope Glycoprotein

The interferon-induced transmembrane (IFITM) proteins have been recently shown to restrict HIV-1 and other viruses. Here, we provide evidence that IFITM proteins, particularly IFITM2 and IFITM3, specifically antagonize the HIV-1 envelope glycoprotein (Env), thereby inhibiting viral infection. IFITM...

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Bibliographic Details
Main Authors: Jingyou Yu, Minghua Li, Jordan Wilkins, Shilei Ding, Talia H. Swartz, Anthony M. Esposito, Yi-Min Zheng, Eric O. Freed, Chen Liang, Benjamin K. Chen, Shan-Lu Liu
Format: Article
Language:English
Published: Elsevier 2015-10-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715009523

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http://www.sciencedirect.com/science/article/pii/S2211124715009523

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