Inhibition of Pyk2 blocks lung inflammation and injury in a mouse model of acute lung injury

Inhibition of Pyk2 blocks lung inflammation and injury in a mouse model of acute lung injury

<p>Abstract</p> <p>Background</p> <p>Proline-rich tyrosine kinase 2 (Pyk2) is essential in neutrophil degranulation and chemotaxis in vitro. However, its effect on the process of lung inflammation and edema formation during LPS induced acute lung injury (ALI) remains un...

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Bibliographic Details
Main Authors: Duan Yingli, Learoyd Jonathan, Meliton Angelo Y, Leff Alan R, Zhu Xiangdong
Format: Article
Language:English
Published: BMC 2012-01-01
Series:Respiratory Research
Subjects:
inflammation
lipopolysaccharide
lung
neutrophils
Pyk2
Online Access:http://respiratory-research.com/content/13/1/4

Internet

http://respiratory-research.com/content/13/1/4

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