Regulatory Factor X1 Downregulation Contributes to Monocyte Chemoattractant Protein-1 Overexpression in CD14+ Monocytes via Epigenetic Mechanisms in Coronary Heart Disease

Regulatory Factor X1 Downregulation Contributes to Monocyte Chemoattractant Protein-1 Overexpression in CD14+ Monocytes via Epigenetic Mechanisms in Coronary Heart Disease

Monocyte chemoattractant protein 1 (MCP1) affects the chemotaxis of monocytes and is a key chemokine closely related to the development of atherosclerosis (AS). Compared with healthy controls, coronary heart disease (CAD) patients show significantly upregulated plasma concentrations and mRNA express...

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Bibliographic Details
Main Authors: Sujie Jia, Shuang Yang, Pei Du, Keqin Gao, Yu Cao, Baige Yao, Ren Guo, Ming Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Genetics
Subjects:
monocytes
histone acetylation
monocyte chemoattractant protein-1
regulatory factor X1
epigenetics
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.01098/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2019.01098/full

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