Dkk2 promotes neural crest specification by activating Wnt/β-catenin signaling in a GSK3β independent manner

Neural crest progenitors are specified through the modulation of several signaling pathways, among which the activation of Wnt/β-catenin signaling by Wnt8 is especially critical. Glycoproteins of the Dickkopf (Dkk) family are important modulators of Wnt signaling acting primarily as Wnt antagonists....

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Bibliographic Details
Main Authors: Arun Devotta, Chang-Soo Hong, Jean-Pierre Saint-Jeannet
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-07-01
Series:eLife
Subjects:
Wnt
Dkk
Online Access:https://elifesciences.org/articles/34404