Qualitative modeling identifies IL-11 as a novel regulator in maintaining self-renewal in human pluripotent stem cells

Qualitative modeling identifies IL-11 as a novel regulator in maintaining self-renewal in human pluripotent stem cells

Pluripotency in human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) is regulated by three transcription factors - OCT3/4, SOX2 and NANOG. To fully exploit the therapeutic potential of these cells it is essential to have a good mechanistic understanding of the maintenance of...

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Bibliographic Details
Main Authors: Hedi ePeterson, Raed eAbu Dawud, Abhishek eGarg, Ying eWang, Jaak eVilo, Ioannis eXenarios, James eAdjaye
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-10-01
Series:Frontiers in Physiology
Subjects:
Embryonic Stem Cells
regulatory networks
self-renewal
pluripotency
boolean modeling
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2013.00303/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2013.00303/full

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