Cold-Inducible SIRT6 Regulates Thermogenesis of Brown and Beige Fat

Cold-Inducible SIRT6 Regulates Thermogenesis of Brown and Beige Fat

Promoting development and function of brown and beige fat may reduce obesity. Here, we show that fat SIRT6 expression is markedly induced by cold exposure and a β-adrenergic agonist. Deletion of SIRT6 in adipose tissue impairs the thermogenic function of brown adipocytes, causing a morphological “wh...

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Bibliographic Details
Main Authors: Lu Yao, Xiaona Cui, Qi Chen, Xiaoying Yang, Fude Fang, Jun Zhang, Guoqing Liu, Wanzhu Jin, Yongsheng Chang
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Cell Reports
Subjects:
SIRT6
obesity
adipose tissue
thermogenesis
phosphor-ATF2
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717309002

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http://www.sciencedirect.com/science/article/pii/S2211124717309002

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