Short Hairpin RNA Silencing of PHD-2 Improves Neovascularization and Functional Outcomes in Diabetic Wounds and Ischemic Limbs.

Short Hairpin RNA Silencing of PHD-2 Improves Neovascularization and Functional Outcomes in Diabetic Wounds and Ischemic Limbs.

The transcription factor hypoxia-inducible factor 1-alpha (HIF-1α) is responsible for the downstream expression of over 60 genes that regulate cell survival and metabolism in hypoxic conditions as well as those that enhance angiogenesis to alleviate hypoxia. However, under normoxic conditions, HIF-1...

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Main Authors: Kevin J Paik, Zeshaan N Maan, Elizabeth R Zielins, Dominik Duscher, Alexander J Whittam, Shane D Morrison, Elizabeth A Brett, Ryan C Ransom, Michael S Hu, Joseph C Wu, Geoffrey C Gurtner, Michael T Longaker, Derrick C Wan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4788284?pdf=render

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http://europepmc.org/articles/PMC4788284?pdf=render

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