Fibroadipogenic progenitors are responsible for muscle loss in limb girdle muscular dystrophy 2B

Fibroadipogenic progenitors are responsible for muscle loss in limb girdle muscular dystrophy 2B

Fibroadipogenic precursor cells (FAPs) contribute to fibrosis and adipogenic replacement in muscular dystrophies. Here, the authors show that FAPs contribute to adipogenic loss in mouse models of limb girdle muscular dystrophy 2B via a mechanism dependent on expression of Annexin A2, and that this p...

Full description

Bibliographic Details
Main Authors: Marshall W. Hogarth, Aurelia Defour, Christopher Lazarski, Eduard Gallardo, Jordi Diaz Manera, Terence A. Partridge, Kanneboyina Nagaraju, Jyoti K. Jaiswal
Format: Article
Language:English
Published: Nature Publishing Group 2019-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10438-z

Internet

https://doi.org/10.1038/s41467-019-10438-z

Similar Items