Cysteine catabolism and the serine biosynthesis pathway support pyruvate production during pyruvate kinase knockdown in pancreatic cancer cells

Cysteine catabolism and the serine biosynthesis pathway support pyruvate production during pyruvate kinase knockdown in pancreatic cancer cells

Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with limited treatment options. Pyruvate kinase, especially the M2 isoform (PKM2), is highly expressed in PDAC cells, but its role in pancreatic cancer remains controversial. To investigate the role of pyruvate kinas...

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Bibliographic Details
Main Authors: Lei Yu, Shao Thing Teoh, Elliot Ensink, Martin P. Ogrodzinski, Che Yang, Ana I. Vazquez, Sophia Y. Lunt
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Cancer & Metabolism
Subjects:
Pyruvate kinase
PKM
Pancreatic cancer
Liquid chromatography mass spectrometry
Metabolism
Online Access:https://doi.org/10.1186/s40170-019-0205-z

Internet

https://doi.org/10.1186/s40170-019-0205-z

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